Give your body what it needs

by Milan Pantovic August 21, 2016

Muscle fatigue can be described as decline in muscle force and power capacity. During that period many muscle properties such as: action potential, extracellular and intracellular hydrogen ions, intracellular metabolites are changing.

A range of mechanisms have been identified that contribute to the decline of performance. For easier understanding we will divide them in two main groups:

  • central (brain) and,
  • peripheral (muscles themselves) factors.

Today we will focus only on one factor –blood lactate levels. During exercise, increase in blood lactate concentration is often considered as one of the major causes of muscle fatigue. In their study (Ishii & Nishida, 2013)  found that blood lactate concentration reflects muscle metabolism, rather than respiratory and circulatory responses, and that muscle activity might convey fatigue-related information to the brain during load intensity when muscle fatigue occurs. Group of Japanese scientists (Aoki et al. 2012) noticed that adequate hydration with molecular hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. In crossover double-blind manner; they were given either molecular hydrogen water or placebo water for one week intervals. Subjects were requested to use a cycle ergometer at a 75 % maximal oxygen uptake (VO2) for 30 min, followed by measurement of peak torque and muscle activity throughout 100 repetitions of maximal isokinetic knee extension. Oxidative stress markers and creatine kinase in the peripheral blood were sequentially measured. Authors noticed that oral intake of molecular hydrogen water prevented an elevation of blood lactate during heavy exercise. Peak torque of placebo significantly decreased during maximal isokinetic knee extension, suggesting muscle fatigue, but peak torque after ingestion of molecular hydrogen water didn’t decrease at early phase. 

Exercise may induce oxidative stress (condition when buildup of free radicals overwhelms body’s ability to eliminate them) through various pathways such as electron leakage within mitochondria, auto-oxidation of the catecholamine, NADPH activity, or ischemia/reperfusion. Molecular hydrogen as a smallest molecule in universe can easily penetrate into subcelular compartments and selectively neutralize only harmful hydroxyl radicals. Also molecular hydrogen increase body’s self protection system. It is suggested that Molecular Hydrogen may be suitable hydration for recreational but also for professional athletes, as well.






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Aoki, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical gas research, 2(1), 1. Link to full text

Ishii, H., & Nishida, Y. (2013). Effect of lactate accumulation during exercise-induced muscle fatigue on the sensorimotor cortex. Journal of physical therapy science, 25(12), 1637-1642. Link to full text


Milan Pantovic
Milan Pantovic